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March 16, 1946

PRIVINE DEPENDENCE OF TWO YEARS' DURATION

Author Affiliations

Washington, D. C.

JAMA. 1946;130(11):702-703. doi:10.1001/jama.1946.02870110026008
Abstract

Privine hydrochloride, a brand of naphazoline, was first described by Hild in April 1941 as a preparation to reduce swelling of the nasal mucosa. Hild stated that "one important advantage of privine, compared with epinephrine, lies in the fact that it causes no reactive hyperemia and that it has only a relatively slight toxicity, if any." The drug appeared on the American market in October 1942. According to Fabricant and Van Alyea "the 0.1 per cent solution of privine hydrochloride is a nontoxic nasal vasoconstrictor which has given satisfactory use in rhinologic practice." In August 1944 Gol-lom reported persistent nasal congestion in more than 30 cases following the use of privine. Feinberg and Friedlaender later reported over 75 eases in which symptoms of nasal congestion were aggravated or prolonged by the continued use of privine. The following case may be of the longest duration which has yet been noted:

Mrs.

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