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March 16, 1946


Author Affiliations

East Orange, N. J.

JAMA. 1946;130(11):733. doi:10.1001/jama.1946.02870110057024

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To the Editor:—  The article on page 1016 of The Journal, Dec. 8, 1945, exemplifies a lack of knowledge concerning the dynamics of action of Latrodectus mactans toxin. The toxic action mimics overdosages from strychnine, physostigmine and neostigmine. The treatment of choice, as far as drugs are concerned, is to use curare or drugs with a curare-like action. The extreme pain and myotonia may be relieved in five minutes, not six and one-half hours, by the intramuscular or intravenous use of a sterile 25 per cent solution of magnesium sulfate.

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