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March 23, 1946


JAMA. 1946;130(12):814. doi:10.1001/jama.1946.02870120060022

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To the Editor:—  In the paper on "Nocturnal Gastric Secretion in Duodenal Ulcer" by Sandweiss and others in The Journal, February 2, the following data were presented:

  1. Both normal persons and patients with duodenal ulcer secrete acid gastric juice during the night of approximately the same hydrochloric acid concentration following 6 p. m. meals.

  2. Under the same conditions as 1 the volume of the gastric juice obtained by continuous suction is approximately the same.

  3. When intermittent single aspirations are performed, duodenal ulcer patients have a greater volume of gastric juice than normal persons, whereby it is shown that this increased volume is not caused by hypersecretion but by delayed emptying.

It seems that so wedded is the mind of gastroenterologists to the importance of hypersecretion and increased hydrochloric acid in duodenal ulcer that quite other evidence is discussed by them as though it supported their attitude. Thus

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