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May 16, 1953


JAMA. 1953;152(3):259-260. doi:10.1001/jama.1953.03690030059014

Histological Lesions in Snake Poisoning.  —Drs. M. Freitas Amorim, R. Franco de Mello, and F. Saliba, of the São Paulo Butantan Institute, recently published a report on the histological lesions found in 24 animals inoculated with snake venom. The first 15 animals (8 rabbits and 7 rats) were injected with the venom of Bothrops jararaca Wied 1824, and the second lot of 9 animals (4 rabbits, 2 rats, and 3 dogs) were inoculated with the venom of Crotalus terrificus terrificus Laurentius 1786. Two rabbits were inoculated intravenously, three dogs received intramuscular injections, and the rest were injected subcutaneously. The animals were autopsied from 5 minutes to 24 days after the first injection. The doses (0.25 to 50 mg.) were administered all at once or over several consecutive days.Besides severe hemorrhage and edema with coagulation necrosis of the subcutaneous tissue and the voluntary muscles at the site of injection, hemorrhages

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