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May 16, 1953


JAMA. 1953;152(3):265. doi:10.1001/jama.1953.03690030065019

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Isoniazid Therapy in Tuberculous Meningitis.  —In a recent Istanbul University medical school periodical Ord. Prof. Sedat Tavat, attending physician at the Admiral Bristol American Hospital, and his associates, Drs. N. Yeginsu, H. Arpacioglu, and F. Turnaoglu, published a report of a case of tuberculous meningitis that responded well to isoniazid therapy. A week prior to admission to the hospital, the patient, a girl 14 years old, had a temperature of 39 C, a severe headache, chills, nausea, and vomiting; she had been given penicillin therapy without effect. On admission to the hospital the patient had a temperature of 39.5 C, was semiconscious and agitated, had photophobia, strabismus, an enlarged right pupilla, and a stiff neck, and did not respond to stimuli. Kernig's and Brudzinski's signs were positive; Babinski's reflex was negative; dermographia was present; the pulse was full and regular at 98 beats a minute; and the blood pressure was

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