During the last eight years great progress has been made in the treatment of infections of the urinary tract. The diagnostic work and the experimental and clinical observations necessary for the foundation of this progress had already been accomplished, but they had not become common knowledge. Before therapeutic advance could be made, a study of the micro-organisms commonly found in the urinary tract had to be supplemented by possible methods of treatment of sufficient value to interest the experimental workers in this field.
As recently as ten years ago it was felt that patients complaining of frequency, urgency and burning on urination did so because the urine excreted by the kidneys was more acid than comfortably could be borne by the mucous membrane of the urinary tract. Soon, however, it was discovered that these patients were relieved when the acidity of the urine was increased, which appeared paradoxic. Cultures of
CLARK AL. SULFANILAMIDE IN TREATMENT OF NONSPECIFIC INFECTIONS OF THE URINARY TRACT. JAMA. 1939;112(8):719–723. doi:10.1001/jama.1939.02800080039009