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To the Editor:—
Following the publication of the article Hypoglycemic Fatigue by Karlan and Cohn in the March 2 issue of The Journal, in which it was pointed out that no beneficial effects with atropine were obtained in cases of hypoglycemia, one of us had an opportunity to discuss the paper with Dr. Portis. Dr. Portis and Dr. Alexander had observed elevation of the blood sugar, normal glucose tolerance curves and relief from symptoms in other cases of hypoglycemia after the administration of atropine. As a result of our talk it is felt that two points in our paper should be reemphasized. In our cases atropine did not prevent the occurrence of hypoglycemic blood levels during the course of our intravenous glucose tolerance tests. It must be admitted that in 4 of our cases injected glucose was removed from the blood at a slower rate after atropine than without it.
Cohn C. HYPOGLYCEMIC FATIGUE. JAMA. 1946;130(15):1047. doi:10.1001/jama.1946.02870150065020