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April 13, 1946

HODGKIN'S DISEASE AND GIANT FOLLICULAR LYMPHADENOPATHY

Author Affiliations

Madison, Wis.

JAMA. 1946;130(15):1047. doi:10.1001/jama.1946.02870150065022

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Abstract

To the Editor:—  Under the editorial comment entitled "Hodgkin's Disease and Giant Follicular Lymphadenopathy" in The Journal, March 16, the statement is made, referring to giant follicular lymphadenopathy, "it is curable by mild x-ray therapy." This is incorrect in the opinion of most students of the disease. Although Brill, Baehr and Rosenthal (The Journal, Feb. 28, 1925, p. 668) originally thought this condition benign, they have since reversed this opinion and Baehr, Klemperer and Rosenthal (Am. J. Path.3:550, 1927) look on the disease as a form of lymphosarcoma, which it resembles both clinically and, in later stages, pathologically. Although usually highly responsive to roentgen rays, the disease slowly progresses, has the course of a malignant neoplasm and in our experience is invariably fatal.I bring this to your attention for the statement of curability, if transmitted to relatives of patients, will lead to unnecessary later distress for the

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