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April 13, 1946

Penicillin in the Treatment of Infections

JAMA. 1946;130(15):1053. doi:10.1001/jama.1946.02870150071027

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This is a systematic and workmanlike review of the current status of penicillin in its most familiar therapeutic applications. In a field developing as rapidly as penicillin therapy, it was perhaps inevitable that any such book would be somewhat inadequate by the time it could be published. We believe the list of penicillin-sensitive organisms given here could now be made somewhat more inclusive; likewise the list of penicillin-resistant organisms. The discussion of penicillinase seems scarcely to do justice to this rather useful laboratory agent. The subcutaneous injection of penicillin might have been more clearly revealed as unsatisfactory and undesirable. Something more might now be said about oral administration, although this was perhaps difficult at the time this section was written. Topical therapy by means of troches and ointments would seem to be worth discussion at this time. Another important form of administration, the aerosol, must now be seriously considered, and

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