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April 20, 1946


Author Affiliations

Jersey City, N. J.

JAMA. 1946;130(16):1071. doi:10.1001/jama.1946.02870160017007

Many reactions to penicillin or to toxic impurities contained in individual batches of the extract have been described. Lyons reported such reactions as chills, fever, headache, eosinophilia and other pathologic conditions. Keefer reported urticaria. Other toxic manifestations have been thrombophlebitis, gastrointestinal reaction, contact dermatitis and vesicular dermatitis. Bullous dermatitis was reported by Morris and Downing. Fortunately, none of these reactions were of such severity as to jeopardize the life of the patient. Several references call attention to occasional reactions simulating serum sickness. These reactions may be of such severity as to be alarming. Price, McNairy and White report 1 such case, resulting in severe asthma almost causing the death of their patient. It is my purpose to report another case of delayed sensitization to penicillin of unusual severity.

P. G., a white man aged 23, a physician, was admitted to the Jersey City Medical Center on April 16, 194S because

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