May 30, 1953


Author Affiliations

Meharry Medical College Nashville 6, Tenn.

JAMA. 1953;152(5):474. doi:10.1001/jama.1953.03690050098026

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To the Editor:  —Several weeks ago a paper by T. W. Botsford, H. B. Wheeler, R. A. Newton, and W. E. Jaques entitled "Hypoplasia of Bone Marrow Associated with Radioactive Colloidal Gold Therapy" appeared in The Journal (151:788 [March 7] 1953). These authors, on a basis of studies of six patients with malignant disease and without any quantitative measurements of radioactive material in the marrow or long bones, claimed to have found hypoplasia of the bone marrow of significant proportions. After nearly seven years' experience with radioactive colloidal gold used in the treatment of human disease, our group has never been impressed by any bone marrow alterations when ordinary therapeutic quantities of material were given by the interstitial, intracavitary, or intravenous routes. The last route undoubtedly results in the deposition of some of the colloid in the bone marrow. Only in those cases in which amounts much larger than

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