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May 30, 1953

Amebiasis: Pathology, Diagnosis and Chemotherapy.

JAMA. 1953;152(5):482. doi:10.1001/jama.1953.03690050106036

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The authors have compiled an excellent monograph on present knowledge of Endameba histolytica and amebiasis for the clinician and the laboratory worker. After an introductory historical chapter, there are chapters on endemiology, etiology and pathogenesis, pathology (four chapters, including one on experimental amebiasis in animals), complications and sequelae, symptomatology and clinical manifestations, laboratory diagnosis, prevention and public health aspects, chemotherapy and supportive therapy, and requirements for growth and control of the parasite in vitro.

The authors stress the labile balance between invasiveness of the parasite and resistance and immunity of the host. At one extreme are persons with extensive amebic ulcerations of the intestine and, sometimes, with hepatic abscesses and other metastatic foci. At the other extreme are the healthy carriers whose immune responses prevent tissue invasion and force the ameba to multiply and survive in the lumen of the intestine. The authors apparently do not believe that the latter

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