October 8, 1932


JAMA. 1932;99(15):1247-1249. doi:10.1001/jama.1932.02740670035010

In 1924. Felty1 reported from the Johns Hopkins Hospital five examples of an unusual syndrome, the important features of which were chronic arthritis, splenomegaly and leukopenia. He summarized the common features of the five cases as follows:

The syndrome occurred in persons of middle age, all of whom were undernourished and gave a history of marked loss of weight since the onset of the symptoms. The arthritic process is distinctly chronic, the average duration being four and a half years. In striking contrast to the prolonged course of the disease and the generalized distribution of the pain, which is the presenting symptom of all the patients, the objective finding, both by physical examination and roentgenographic study, is neither widespread nor indicative of a very damaging or destructive process. Indeed, one is rather impressed by the relatively benign nature of the involvement as compared with the typically chronic deforming arthritis

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