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May 4, 1946

PENICILLIN ALONE IN NEUROSYPHILIS

Author Affiliations

Passed Assistant Surgeon (R), United States Public Health Service with the collaboration of; with the technical assistance of; Philadelphia

From the Institute for the Control of Syphilis, University of Pennsylvania and United States Public Health Service cooperating, and the Penicillin-Syphilis Panel of the University Hospital. The Institute, the Departments of Neurology, Ophthalmology, Dermatology and Syphilology, and Pediatrics, and the Division of Venereal Disease Control, Philadelphia City Department of Public Health, and the Philadelphia General, Pennsylvania and Children's hospitals are represented in the authorship.

JAMA. 1946;131(1):1-7. doi:10.1001/jama.1946.02870180003001
Abstract

The Penicillin  Syphilis Group at the University of Pennsylvania has treated 746 patients with penicillin since Nov. 11, 1943. Of these, 283 had neurosyphilis. The average period of observation is 357 days, the longest period of observation being 719 days. One hundred and nineteen had been observed from 120 to 364 days, 55 for 365 to 599 days and 23 for 600 days and over. Thanks to the follow-up workers of the Institute for the Control of Syphilis, 97.7 per cent of these patients have been kept track of and returned for periodic observation and treatment. The material is classified by diagnosis and initial spinal fluid findings in table 1. The patients with negative spinal fluids at the outset showed symptoms against which response could be measured.

POINTS DESERVING EMPHASIS IN THIS MATERIAL  In order to be considered for penicillin treatment, the patient must have presented some

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