June 6, 1953


JAMA. 1953;152(6):533. doi:10.1001/jama.1953.03690060049017

Since the triad of situs inversus, bronchiectasis, and chronic sinusitis, which is known as Kartagener's syndrome, was first reported in 1933, 41 cases have been described in the medical literature. The lesions found in the nasal cavity and paranasal sinuses of patients with Kartagener's syndrome are of a variable nature and include mild or severe sinusitis, nasal polyposis, and hypoplasia of the sinuses. According to Kartagener and Ulrich,1 the simultaneous occurrence of bronchiectasis and sinusitis indicates a coordinated constitutional factor in the paranasal sinuses and bronchial tree that is presumably responsible for localization of infections. The incidence of bronchiectasis is significantly greater in persons with transposition of the viscera than in the general population. Olsen2 describes 14 cases (14.5%) in 85 patients with dextrocardia observed during a 27 year period, 10 of the 14 having nasal polyposis. Katz and his associates3 assert that the increased incidence of

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