Immunologic Relation of Tuberculosis and Leprosy.
—In a recent study, Drs. Nelson Souza Campos, José Rosenberg, and Jamil Aun reported on 40 children from 3 to 14 years old whose parents had leprosy (Hansen's disease). Five of the children were in contact with their parents for from seven months to four years, and 35 of them were isolated immediately after birth. The entire group were cared for in closed surroundings. All of these children had positive reactions to lepromin in annual Mitsuda tests; the reactions had been stable for from two and seven years. The reactions to the last lepromin test preceding the BCG vaccination were as follows: 27 children had doubtful reactions, 11 had 1+ reactions, and 2 had 2+ reactions. The result of a Mantoux test (with 1:10 tuberculin) was negative in all cases.The factors that might have caused positive Mitsuda reactions in these children living in
BRAZIL. JAMA. 1953;152(6):547. doi:10.1001/jama.1953.03690060063022