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November 12, 1949


Author Affiliations

Nashville, Tenn.

JAMA. 1949;141(11):794. doi:10.1001/jama.1949.02910110046021

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To the Editor:—  An editorial on "Insulin Economy" in The Journal (140:1159 [Aug. 6] 1949), calls attention to the fact that the author of the article on which this editorial is based did not propose any theory to explain the action of glycine, when injected subcutaneously, on insulin behavior.Glycine was considered particularly suited to this investigation, largely because of its outstanding specific dynamic action and its detoxifying properties within the animal body. (The author had not become aware of the investigations subsequently quoted in his article at the time when this investigation was begun.) The author had considered it possible that the diabetic state is primarily a disease of the metabolizing tissue cells, of those of muscle in particular, and that the deterioration of the islands of Langerhans is a consequence of this through the excessive demands made on them. Others have no doubt indulged in similar speculation.

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