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Article
June 20, 1953

NUTRITION AND APOENZYMES

JAMA. 1953;152(8):710. doi:10.1001/jama.1953.03690080054016
Abstract

One of the most widely used criteria of nutritive success or failure in experimental nutrition has been the change of body weight. Indeed, the entire concept of indispensability of a given dietary factor rests largely on the maintenance or failure to maintain an increase of body weight in young animals or a steady state in adults. This change in mass in experimental animals is tacitly attributed largely to tissue protein, a concept greatly fortified by the demonstration1 of the large loss of protein from various tissues of the body during relatively brief periods of inanition. Later it was shown2 that in a fast of seven days not only the body weight decreased but also a loss of hepatic protein and a decrease in concentration of various enzymes of the liver occurred. Although these losses in hepatic enzymes are greater than the loss of liver protein, they are related

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