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March 18, 1939

THE CLINICAL APPLICATION OF DUODENAL EXTRACT

Author Affiliations

Philadelphia.

JAMA. 1939;112(11):1094. doi:10.1001/jama.1939.02800110074024

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Abstract

To the Editor:—  Since reporting on the clinical application of duodenal extract (Macallum-Laughton) in the treatment of diabetes (Duncan, G. G.; Shumway, N. P.; Williams, T. L., and Fetter, Ferdinand: Am. J. M. Sc.189:403 [March] 1935), my associates and I have received many inquiries regarding the action of this preparation and the likelihood of its permanent value, but most of all its availability for distribution. At least one pharmaceutic firm has quoted our work as corroborating their questionable observations. We of course were not consulted about having our names used for this purpose.It seems appropriate to recount, through the medium of The Journal, our disappointments, difficulties and the present status of this problem.Following the apparently excellent results with two or three batches of the extract, made up in small quantities, the effect was lost when treatment with material made in large lots was begun. The former

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