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June 1, 1946


JAMA. 1946;131(5):367-372. doi:10.1001/jama.1946.02870220001001

More than two hundred and sixty years ago Thomas Sydenham1 published a clear description of the diagnostic features of acute gout. It would seem that in the course of nearly three hundred years every well educated physician would be familiar with the simple clinical picture presented by Sydenham and thereby be able to recognize the disease in its typical form without difficulty. Such is not the case. Ten years ago Herrick and Tyson2 published a paper entitled "Gout—A Forgotten Disease." That gout is still a forgotten disease as late as 1945, the following case report indicates:

History.—  Mrs. R. W., aged 68, i.i descending a stairway on June 26 twisted her right ankle. Walking became painful and there was swelling of the outer part of the ankle, with black and blue discoloration of the skin. On the night of June 28 at bedtime the right big toe at

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