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June 1, 1946

PREDICTION OF FATE OF THREATENED ABORTION BY PREGNANDIOL

Author Affiliations

Chicago

From the Department of Metabolic and Endocrine Research, Research Institute, Michael Reese Hospital.; The Department of Metabolic and Endocrine Research is in part supported by the Michael Reese Research Foundation.

JAMA. 1946;131(5):378-382. doi:10.1001/jama.1946.02870220012003
Abstract

It has been shown in this laboratory that the determination of pregnandiol excretion in urine (by a qualitative color reaction) can be used as a diagnostic test for pregnancy, with an accuracy similar to that obtained with the Friedman (rabbit) procedure.1 Recently we have been following, by means of the color test, the excretion of pregnandiol in complications of pregnancy, particularly in threatened abortion. It will be demonstrated in this report that the pregnandiol color test can be used to predict with a large degree of accuracy the fate of a threatened abortion, and that it can thus serve as a prognostic guide for the physician.

Pregnandiol is a biologically inactive steroid found in the urine of women. On the basis of the following considerations it is generally accepted to be the urinary excretion product of progesterone, a hormone secreted by the corpus luteum and/or the placenta. 1. Coincident

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