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June 8, 1946

PREVENTION OF ERYTHROBLASTOSIS FETALIS

JAMA. 1946;131(6):525. doi:10.1001/jama.1946.02870230031011
Abstract

A study which may in time result in the development of a practical method for the prevention of erythroblastosis fetalis has been reported by Homburger 1 of Harvard Medical School.

In 1922 Swift2 of the Rockefeller Institute showed that rabbits which received sodium salicylate in daily doses of from 0.16 to 0.2 Gm. per kilogram of body weight and at the same time were given intravenous injections of Streptococcus viridans or of washed sheep red blood cells had a greatly diminished formation of agglutinins, hemolysins and complement fixing antibodies. Homburger immunized groups of guinea pigs and rabbits by repeated intraperitoneal (guinea pigs) or intravenous (rabbits) injection of washed rhesus cells. Half of the animals of each group received 0.16 Gm. per kilogram of sodium salicylate either by stomach tube (guinea pigs) or by subcutaneous injection (rabbits). Seven days after the final injection the plasmas of all animals were titrated

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