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The author's basic thesis stresses the importance, in the production of cardiovascular disease, of the release of the catecholamines, epinephrine, and arterenol into the myocardium and the vascular musculature of the body. He presents many cogent arguments in support of this thesis and attempts, more or less successfully, to show that the actions of such amines on cardiac and vascular tissue are capable of inducing both the functional and structural alterations seen clinically.
On page 525, the author says, "Some time-honored but out-dated mechanistic views which interpret cardiovascular functional and structural changes solely in terms of coronary flow and of hemodynamic factors are no longer tenable. They must be revised in the light of present-day knowledge of ubiquitous neuroendocrine and endocrine biochemical influences upon cardiovascular tissue metabolism and of their interplay. Teleological auxiliary hypotheses are becoming increasingly superfluous and should be discarded." He points out that much progress has been
Hormonal and Neurogenic Cardiovascular Disorders: Endocrine and Neuro-Endocrine Factors in Pathogenesis and Treatment.. JAMA. 1953;152(11):1080–1081. doi:10.1001/jama.1953.03690110094040