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June 22, 1946


JAMA. 1946;131(8):668. doi:10.1001/jama.1946.02870250022009

From his observations in animal experiments on revival after exsanguination, Negovski1 emphasizes that death does not always occur abruptly. The final changes responsible for true biologic death are usually preceded by a period of so-called clinical death, which begins when heart action and respiration cease. Clinical death in many instances represents a reversible transition from life to death. Intra-arterial administration of blood under pressure is not a complete method of resuscitation; in fact, the results have been somewhat disappointing. Artificial respiration, of equal importance, must be started immediately after revival and must be sufficiently intensive. This prompt application, necessary for starting the first spontaneous gasp and indirectly for early return of eye reflexes, may decide the outcome of the entire effort. The appearance of the spontaneous gasp in the second minute of revival leads to recovery of nearly 100 per cent of animals, while a delay of nine minutes

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