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June 22, 1946

The Sulphonamides in Theory and Practice

JAMA. 1946;131(8):709. doi:10.1001/jama.1946.02870250063026

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In the preface the author states that "the spate of new drugs of this class seems to be waning and recent work has been concerned more with consolidating our knowledge of the old ones. Time therefore seems opportune to attempt a brief survey of the facts which have been evolved." He has succeeded in crystallizing the present status of sulfonamide therapy, drawing heavily on the literature rather than on his personal experience for his information. There is an excellent summary of the mode of action and the pharmacology of the sulfonamides. Included in the discussion are phthalylsulfathiazole and homosulfanilamide. There is a well timed chapter on common abuses of the sulfonamides. In a concluding section on sulfonamides or penicillin the author devotes only one and one-half pages to this important feature of the subject. In general, the material is presented clearly and concisely. Pertinent references to the literature are given.

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