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June 29, 1946

Clinical Notes, Suggestions and New Instruments

JAMA. 1946;131(9):741-743. doi:10.1001/jama.1946.02870260025006

ACUTE SYPHILITIC NEPHROSIS SUCCESSFULLY TREATED WITH PENICILLIN  J. H. Barr Jr., M.D.; H. N. COLE, M.D.; J. R. DRIVER, M.D.; ROSCOE D. LEAS, M.D.; MAX MILLER, M.D., and L. G. STRAUSS, M.D. ClevelandThe nephrotic syndrome is defined as a clinical symptom complex characterized by profuse proteinuria, hypoalbuminemia and edema without serious renal insufficiency or hypertension. It may be seen in a variety of conditions and has been observed in connection with acute syphilis.1


History.—  J. Y., a white man aged 31, was first

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