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To the Editor:
—In The Journal, August 20, in an article by Dr. Dinsmore on "Hyperthyroidism in Children," page 638, I note the following:We have now operated on forty-three patients with hyperthyroidism, with two deaths, one of which occurred before the advent of compound solution of iodine.According to his memoirs, Lugol made extensive use of compound solution of iodine in 1827, some 105 years ago: this in the treatment of goiter.Again, on page 659, under the title "The Medical History of Sir Walter Scott," it is stated:In one attack lasting six hours he took 6 grains of opium, 3 of scopolamine and nearly 200 drops of laudanum.Disregarding the question of the identity of scopolamine and hyoscine and the fact that 1/100 grain of scopolamine or its salts might be considered a fair dose, scopolamine seems to have been discovered in crystalline form by Bender in
Macartney WN. HYOSCYAMUS AND HYOSCINE. JAMA. 1932;99(16):1373. doi:10.1001/jama.1932.02740680069030