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July 6, 1946

KLEBSIELLA PNEUMONIA TREATED WITH STREPTOMYCIN

Author Affiliations

South Bend, Ind.

JAMA. 1946;131(10):821-822. doi:10.1001/jama.1946.02870270021008
Abstract

A small percentage of pneumonias have as their etiologic agent Klebsiella pneumoniae, an organism belonging to the Friedländer group. Bullowa reports this organism as the causative agent in 1.1 per cent of 4,416 cases of pneumonia. Julianelle reports an incidence of about 1 per cent. Pneumonia caused by Klebsiella pneumoniae carries with it a mortality rate reported to be between 71 and 97 per cent.

This case is reported because of the usual high mortality rate, the striking results obtained with the administration of streptomycin, and because, in the literature, there had been no case reported in which streptomycin had been used in the treatment of Klebsiella pneumonia.

Streptomycin was described in January 1944 by Schatz, Bugie and Waksman. This antibiotic is characterized by its bacteriostatic activity against certain gram positive and gram negative organisms. Heilman reported in vivo and in vitro experiments on the effects of streptomycin on the

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