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July 13, 1946

Current Comment

JAMA. 1946;131(11):898-899. doi:10.1001/jama.1946.02870280024013

THE PROMISE OF CHEMOTHERAPY FOR HODGKIN'S DISEASE  Studies under the auspices of the Chemical Warfare Service and related agencies on the mode of action cf various toxic compounds may lead to the discovery of compounds with unanticipated therapeutic values. Gilman and Phillips1 recently presented the first of a series of papers on compounds related to mustard gas. Mustard gas, bis (beta chloroethyl) sulfide, is a highly cytotoxic compound exerting its effect on a wide variety of tissues but with a certain predilection for tissues showing proliferative activity. Replacement of the sulfur by nitrogen gives rise to compounds which are called nitrogen mustards. These compounds do not have the undesirable physical properties or the extreme chemical reactivity of mustard gas but appear to have similar cytotoxic effects. They can be prepared as water soluble crystalline compounds in the form of their hydrochloride salts. Elaborate studies of the

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