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July 20, 1946


JAMA. 1946;131(12):975-976. doi:10.1001/jama.1946.02870290025012

The experimental arrest of cephalic blood flow in animals and its resultant effects have excited the interest of numerous investigators since the work of Astley Cooper in 1836. He observed that death does not immediately follow the ligation of the two carotid and the two vertebral arteries and that spasms may occur before the cessation of respiration. The attention of workers was directed both to the functional and to the histopathologic effects on the brain and nervous system of such an arrest of blood flow. Particular study has been made of the exact duration of time during which the circulation can be arrested before nerve cells die and vital centers cannot be revived.

Four technics have been employed to produce a temporary arrest of cerebral circulation in animals: (1) vessel ligation with occlusion of one or all of the chief cerebral arteries, (2) production of temporary cardiac arrest, (3) occlusion

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