[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.87.3. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 8, 1953

PATHOGENESIS OF ESSENTIAL HYPERTENSION

JAMA. 1953;152(15):1435-1436. doi:10.1001/jama.1953.03690150039013
Abstract

The pathogenesis of essential hypertension, which accounts for 95% of the cases of hypertension seen clinically, is still unknown in spite of extensive clinical and laboratory studies during the past 20 years. However, these studies have indicated neurogenic, endocrine (anterior pituitary—adrenal cortex), and renal changes in pathophysiology that may have pathogenetic significance. Thus some patients with essential hypertension show evidence of increased vasomotor tone, others show mild disturbances in water and sodium chloride metabolisms, and some show increased plasma concentrations of vasoexcitatory material (VEM) and vasodepressor material (VDM), produced by the kidney and liver, respectively. Whether these changes connote several pathogenetically distinct types of hypertension or whether essential hypertension is a single clinical entity with varying degrees of alteration in different body functions remains to be determined.

Since the pathogenesis of essential hypertension is unknown, treatment is based on pathophysiology and empiricism. Moreover, information about the long-term effects of presently

First Page Preview View Large
First page PDF preview
First page PDF preview
×