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This monograph is the result of 20 years of laboratory investigation on uric acid metabolism and clinical study of gout. The more recent biochemical advances in this field are recorded, with emphasis on clinical aspects.
Most of the phases of gout are covered briefly. Of particular interest is the discussion of intermediary metabolism of uric acid, which includes a review of the precursors of uric acid, the miscible pool, and turnover rate of labeled uric acid. Of equal interest is the section on concentration of urates in serum and renal exchange of urates. A discussion of probenecid (Benemid), a uricosuric agent, is well presented. The remainder of the material covers symptoms, diagnosis, and treatment of gout.
While the roentgenograms are good, their value would have been enhanced if photographs had been included to coincide with the various roentgenologic phases. The bibliography is fairly comprehensive. The material is accurately presented, although
Gout and Gouty Arthritis.. JAMA. 1953;152(15):1492. doi:10.1001/jama.1953.03690150096034