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January 7, 1950

STREPTOMYCIN COMBINED WITH SURGERY IN THE TREATMENT OF BONE AND JOINT TUBERCULOSIS

Author Affiliations

New York

From the Clinic of the New York Orthopaedic Dispensary and Hospital.

JAMA. 1950;142(1):1-7. doi:10.1001/jama.1950.02910190003001
Abstract

Reports on the effect of streptomycin in the treatment of tuberculosis of bones and joints for the most part have been inconclusive or unpromising.1 Apparently most patients were treated with the antibiotic alone, without concomitant surgical measures. Brock,2 Morgan and Bosworth3 reported success with streptomycin in the treatment of tuberculous sinuses. Bickel and others4 described 16 cases with streptomycin therapy, some in conjunction with fusion procedures, with 9 good results. These included 2 good results in synovial tuberculosis of the knee without surgical operation. Pulaski and associates5 treated tuberculosis in 24 cases, 18 of the spine and 6 of the extremities, with 6 good results. Michele and Krueger reported success in 12 cases with the use of both streptomycin and surgery.6 The largest and most carefully studied series of cases, with the best results, was that reported by Bosworth and others.7

The purpose

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