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August 15, 1953


JAMA. 1953;152(16):1550. doi:10.1001/jama.1953.03690160050017

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Prognostic Significance of the Size of a Malignant Tumor of the Breast.  —Hitherto it has largely been taken for granted that the smaller a malignant tumor in the breast the better is the prognosis. Prof. Leiv Kreyberg, who is in charge of the Institute for General and Experimental Pathology at the Oslo University, has lately challenged the accuracy of this assumption and, in conjunction with Dr. Tor Christiansen, has undertaken a critical scrutiny of 974 cases of cancer of the breast examined in the period 1933-1942. This scrutiny, carried out in 1952, concerned patients with a minimum observation period of 10 years and in many cases a much longer observation period. Among these patients were 56 with tumors whose size at the first examination was that of a Norwegian hazel nut or smaller. In 10 of these cases the size of the tumor was that of only a pea or

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