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August 10, 1946

SYNTHETIC FOLIC ACID THERAPY IN PERNICIOUS ANEMIA

Author Affiliations

New York

From the medical and pathologic services of St. Luke's Hospital.

JAMA. 1946;131(15):1201-1207. doi:10.1001/jama.1946.02870320019005
Abstract

Our purpose in this communication is to show the responses of 6 unselected patients with addisonian pernicious anemia to various doses of synthetic folic acid as reflected by changes in the hemoglobin and the red cell and reticulocyte counts.

The experimental and laboratory data on the clinical and biologic activities of the Lactobacillus casei factor have been thoroughly discussed by Moore and his associates1 and the clinical aspects of folic acid in the treatment of patients with macrocytic hyperchromic anemia were recently reported by Spies.2 Further evaluation of the antianemic properties have been added by Doan and his associates3 and by Spies.4

METHODS OF STUDY  All patients in this series were hospitalized during the full period of observation. Control intervals of from three to nine days were required for investigation and diagnosis.The diagnosis of addisonian pernicious anemia was made on the patient's history, physical and

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