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August 10, 1946

Theorie der Muskelkontraktion

JAMA. 1946;131(15):1252. doi:10.1001/jama.1946.02870320070031

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The first part of this monograph is devoted to a review of existing knowledge on the microstructure of muscle fibers. The relation of this feature to the muscle proteins and to the molecular changes which occur on contraction is considered in some detail. Discussion of this material is correlated with the development of the author's theory of muscular contraction. The role of potassium in muscular contraction is also reviewed. This is a field of investigation to which the author has made a personal contribution and his theory of muscular contraction emphasizes the importance of potassium in the contraction process. Following a brief history of the various theories of muscular contraction the author presents his own views in some detail. He suggests that myosin, the contractile element of the muscle fiber and the chief component of the Q band form a complex with potassium and glycogen. This complex is thought to

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