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September 5, 1953

NALORPHINE (NALLINE) ANTAGONISM TO RACEMORPHAN (DROMORAN) INTOXICATION

JAMA. 1953;153(1):26-27. doi:10.1001/jama.1953.02940180028010
Abstract

Experiments with laboratory animals indicate that nalorphine (Nalline) is effective in antagonizing most of the effects of morphine, codeine, dihydromorphinone (Dilaudid), metopon, methadone, and meperidine (Demerol). Successful clinical use of nalorphine to antagonize the respiratory depression caused by morphine, dihydromorphinone, methadone, and meperidine has been reported. Chase, Boyd, and Andrews have reported successful treatment of dihydromorphinone and racemorphan poisoning with nalorphine. We have had the opportunity to confirm the dramatic efficacy of nalorphine in another case of racemorphan intoxication. The unusual circumstances involved in this case permit the drawing of certain conclusions concerning the pharmacological activity of both racemorphan and nalorphine.

REPORT OF A CASE

A 54-year-old white woman entered the hospital in December, 1952, because of generalized carcinomatosis. Six months previously she had been treated for carcinoma of the uterus with radium implants and subsequent total hysterectomy. For a month prior to admission she had been bedridden and had

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