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October 29, 1932

BASOPHILIC ADENOMA OF THE PITUITARY (PITUITARY BASOPHILISM-CUSHING SYNDROME)

Author Affiliations

Detroit

From the Department of Internal Medicine, Harper Hospital. Reported at a staff conference, Oct. 16, 1931.

JAMA. 1932;99(18):1498-1500. doi:10.1001/jama.1932.27410700001010
Abstract

Recently Cushing1 described a syndrome associated with basophilic adenomas of the pituitary. Twelve cases were reported. As the number of recognized cases with postmortem observations are rare, I am adding another.

The syndrome is characterized by "(1) a rapidly acquired, peculiarly disposed and usually painful adiposity (in one instance representing a 40 per cent gain in weight), confined to the face, neck and trunk, the extremities being spared; (2) a tendency to become round shouldered (kyphotic) even to the point of measurable loss of height associated with lumbospinal pains; (3) a sexual dystrophy shown by early amenorrhea in the females and ultimate impotence in the males; (4) an alteration in normal hirsuties shown by a tendency to hypertrichosis of face and trunk in all the females as well as the preadolescent males and possibly the reverse in adult males; (5) a dusky or plethoric appearance of the skin with

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