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May 13, 1939

LOCAL AND SYSTEMIC EFFECTS FROM INHALATION OF STRONG SOLUTIONS OF EPINEPHRINE

Author Affiliations

SAN FRANCISCO; SAN JOSE, CALIF.; SAN FRANCISCO

From the Departments of Pharmacology and of Pathology, Stanford University School of Medicine, San Francisco, and the Santa Clara County Hospital.

JAMA. 1939;112(19):1929-1933. doi:10.1001/jama.1939.02800190043011
Abstract

Inhalation of vaporized 1 per cent solution of epinephrine is extensively used in the relief of bronchial asthma.1 This is a convenient way of obtaining directly the well known bronchodilator action of epinephrine without the necessity of hypodermic injection. The clinical results have been generally good as to relief of asthmatic attacks. At least ten atomizers are advertized as specially designed for this purpose, and, in addition, 1 per cent solution of epinephrine is the active ingredient of a large number of trade-marked anti-asthma products offered to the public. In spite of the widespread use of this strong concentration of epinephrine, no reports have been made as to possible local irritative effects on the respiratory tract. When it is remembered that deep inhalations of this potent drug are practiced almost indefinitely in a chronic disease state, it would appear desirable to understand more fully and definitely, if possible, the

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