The participation of the U. S. Public Health Service in the evaluation of various treatment methods for early syphilis may be grouped in three broad phases. The first was the evaluation with the Cooperative Clinical Group of the results of standard therapy of weekly injections of arsphenamine and heavy metal. This study was conducted in the period 1930-1935. The second was the field study evaluation of massive arsenotherapy conducted with the New York and Midwestern groups of cooperating clinics that took place during the ten year period 1933-1943.
The present communication is a progress report on an evaluation study of the results in early syphilis of various intensive treatment schedules utilizing penicillin alone or with adjunctive therapy and of certain methods and schedules of intensive arsenotherapy. The records on which the study is based are from sixteen rapid treatment centers. These centers are members of a group of some fifty
HELLER R. RESULTS OF RAPID TREATMENT OF EARLY SYPHILIS. JAMA. 1946;132(5):258-263. doi:10.1001/jama.1946.02870400006002