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October 5, 1946


JAMA. 1946;132(5):284-285. doi:10.1001/jama.1946.02870400032010

Two principal arguments have been advanced to justify the administration of penicillin by inhalation: the difficulty and the cost of the intramuscular or intravenous methods and the possibility that there may be a more direct action of penicillin when this antibiotic is placed in more intimate contact with the infecting organism, as is the case when sprayed into the respiratory tract in the presence of respiratory infections. Several technics of nebulizing solutions containing penicillin have been employed. Vermilye,1 for example, used an apparatus consisting of an oxygen tank equipped with a valve for controlling the flow of oxygen at about 4 liters per minute. The oxygen from this tank is allowed to flow through a Vaponephrin nebulizer by tubing attached to the intake arm. At some point in the rubber tubing a Y tube is inserted, leaving one arm of the Y free and the tube of the nebulizer

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