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November 7, 1953

The Metabolism of the Tubercle Bacillus

JAMA. 1953;153(10):989. doi:10.1001/jama.1953.02940270095036

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This is a timely compilation of the literature and the authors' experiences that adds a needed reference volume to those of Calmette and Wells. Long, in the foreword, notes that a great deal of information accumulated in the last 30 years is coordinated here. Both authors are pioneers in the study of important phases of the problem under consideration, and their personal investigations led to the preparation of this monograph. Drea is a student of subsurface growth and Andrejew, of the mechanisms involved in respiration of the bacillus. The chapters on nutrition and respiration cover the fundamental physiology of tubercle bacilli, with a comprehensive review of the older literature. The chapter on depth growth is the most important in the monograph. It is based on the work of Drea and Boissevain, 10 years ago, that resulted in striking rapidity of growth from minute inoculums in simple mediums. Andrejew, through special

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