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November 2, 1946

Clinical Notes, Suggestions and New Instruments

JAMA. 1946;132(9):514-515. doi:10.1001/jama.1946.02870440028007


Streptomycin Therapy  WILLIAM P. SHIELDS, M.D. Providence, R. I.Meningitis due to Escherichia coli is a rare disease at the Charles V. Chapin Hospital. During the ten year period Jan. 1, 1936 to Jan. 1, 1946, 776 patients with meningitis of all types have been admitted to this hospital. During this period there were not any cases of meningitis due to Esch. coli.Alexander1 recently reported the first instance of treatment of this disease with streptomycin. The patient was a 19 year old soldier. The source of infection was probably a bacteremia secondary to a mixed type of osteomyelitis of the tibia. This patient recovered with no apparent sequelae. There have been reports of the use of the sulfonamides in this disease. Thompson and Quinn,2 Rauch and Krinsky,3 Hollis and Baty,4 Barrett5 and his associates, McLendon and Mitchell6 and

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