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Article
November 21, 1953

Arzneimittel-Synthese

JAMA. 1953;153(12):1133. doi:10.1001/jama.1953.02940290065032

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Abstract

This reference work provides a meeting ground for both the pharmaceutical chemist and the pharmacologist. The author, as did Frankel before him, has carefully blended information on the important steps of synthesis and structureactivity relationships among the members of the many groups of synthetic drugs now available. Thus the reader may comprehend the limitations imposed in drug manufacture on the types of derivatives that could be available and what alterations in pharmacological properties and side-effects might follow from a given modification of chemical structure. The author has had 30 years' experience teaching pharmacy students in German universities and has made numerous investigations in the field, especially in the study of neuropharmacological agents. Much emphasis is placed on this group of drugs, particularly on the synthesis and properties of the local anesthetics that have been derived from cocaine. The scope of the book may not fit in exactly with the interests

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