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November 21, 1953

Human Blood Coagulation and Its Disorders

JAMA. 1953;153(12):1140. doi:10.1001/jama.1953.02940290072059

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Biggs and Macfarlane, having long experience in the field of blood coagulation, have produced a splendid monograph on this subject. The introduction deserves careful reading by all students of medicine regardless of the stage of their career. Those contemplating or involved in medical research will especially appreciate it. The complications and pitfalls of past work in this field are reviewed with care and penetrating skill. The following chapters cover the known aspects of the mechanism of clotting and much that is speculative. The second portion of the volume is devoted to disorders of blood coagulation, including fibrinogen deficiency, hypoprothrombinemia, the coagulation defect in hemophilia, platelet deficiency, natural anticoagulants, thrombosis and anticoagulant therapy, artificial coagulants, and hemostatics. As an addendum an informative section on the newly recognized Christmas disease and Christmas factor has been added.

Appendixes of considerable practical value deal with the differential diagnosis of coagulation defects, the preparation of

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