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November 12, 1932


JAMA. 1932;99(20):1692. doi:10.1001/jama.1932.02740720046013

Insulin has recently been recommended to make thin patients fat, and the clinical results seem striking.1 In a few instances as much as from 10 to 20 pounds (4.5 to 9 Kg.) was gained in almost as many days. This effect was apparently due to the improvement in the patient's appetite. Nahum and Himwich2 of New Haven gave as much as from 45 to 65 units a day to four undernourished but otherwise normal women. They point out, as have others before them, that hunger was greater and that their patients not only consumed much more food but did so with relish and gusto.

This effect of insulin on the appetite is probably due to its stimulating influence on the functional activity of the stomach. Bulatao and Carlson,3 in 1924, first showed that insulin augmented gastric motility and that dextrose injections abolished it. The same effects were

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