The enthusiasm with which sulfanilamide is being used in the treatment of infections of all kinds has tended to minimize a consideration of the possibility of any harmful effects of the drug. Recently the idea has been expressed by many that it might be used prophylactically before certain operations in which the chance of wound infection may be great. It seemed desirable therefore to determine whether or not this drug has any inhibitory effect on wound healing, especially since antiseptics as a group do have such an effect.
The method used was a modification of the technic of Harvey1 and those working with him2 in their experiments on wound healing, in which the tensile strength is used as an indicator of fibroblastic growth. Advantage was taken of their finding that there is a "lag phase" of three or four days before fibroblastic growth reaches a maximum velocity and
BRICKER EM, GRAHAM EA. THE INHIBITORY EFFECT OF SULFANILAMIDE ON WOUND HEALING. JAMA. 1939;112(25):2593-2594. doi:10.1001/jama.1939.02800250017007