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November 30, 1946


JAMA. 1946;132(13):785-786. doi:10.1001/jama.1946.02870480031009a

Inoculation tuberculosis, although infrequent, does occur. A review of the literature indicates that a differentiation must be made between the true primary complex and reinfection tuberculosis. The occurrence of a tuberculous chancre and regional swelling of the lymph node is of great differential aid, especially when accompanied with a change from a negative to a positive tuberculin reaction.

The characteristics of the tuberculous chancre have been well described. Stokes reviewed the subject of primary inoculation tuberculosis of the skin. The following report of a case is considered to be of unusual interest because of the circumstances incident to the occurrence of a typical cutaneous chancre with regional tuberculous lymphadenitis.


The patient was a former army officer, white, aged 25, without any previous significant medical history. He had not knowingly been exposed to tuberculosis. On Jan. 15, 1945 he received multiple superficial wounds of the face, in part

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