The early development and progress in the production of a suspension of calcium penicillin in beeswax and peanut oil has already been reported.1 The initial successful clinical results in the treatment of gonorrhea1c by a single injection of this mixture suggested its use for the treatment of syphilis. It should be emphasized that the primary purpose of this paper is to illustrate an ambulatory method of therapy whereby the patient receives one injection of penicillin instead of the usual eight injections a day.
This study was initiated in August 1944. Since then 75 patients with early syphilis have been treated, of whom 72 were men and 3 women. The ages varied from 18 to 44. There were 37 white and 38 Negro patients. Fifty-six had primary syphilis, of whom only 6 were seronegative, while the remaining 19 had secondary syphilis. All patients were subjected to serologic examination prior
ROMANSKY MJ, REIN CR, Rittman GE. TREATMENT OF EARLY SYPHILIS WITH CALCIUM PENICILLIN-OIL-BEESWAX. JAMA. 1946;132(14):847–851. doi:10.1001/jama.1946.02870490025005