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Article
November 19, 1932

SERUM DISEASE: REPORT OF CASE FOLLOWING INJECTION OF HOMOGENOUS SERUM

Author Affiliations

Kent, Conn.

JAMA. 1932;99(21):1778-1779. doi:10.1001/jama.1932.27410730002011a
Abstract

A boy, aged 14 years, returned to boarding school, Sept. 28, 1931, for the opening of the term. Because he came from a vicinity in which poliomyelitis was then epidemic and because he had been intimately associated with an older brother who was acutely ill at home, the boy was isolated in the school infirmary at once and remained there throughout the period covered in this report. On the morning of October 5, the older brother died of bulbar poliomyelitis. In the hope that it might have some prophylactic effect, the younger boy was given an intramuscular injection of 45 cc. of fresh immune serum in the left buttock. He had had no signs or symptoms of any illness. On the morning of the third day after the serum injection, he began complaining of headache, stiffness in his neck, and pain in the left groin. His temperature had risen from

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